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Research Fund 2004

Research Fund 2004

Professor Raymond C. Stevens, PhD, The Scripps Research Institute, La Jolla, CA

In 2004, the MACPAD Board of Directors granted Professor Raymond Stevens, PhD of The Scripps Research Institute $40,000 to help him continue his research into the development of therapeutics to treat PKU. Currently they are creating and screening a number of mutants of two enzymes, phenylalanine hydroxylase and phenylalanine ammonia lyase. Both of these enzymes are able to degrade phenylalanine and thus lower phenylalanine concentation in the body. The regular form of these enzymes are not stable enough to be injected into the body. Dr. Stevens must study a large number of these mutants. The funds granted by MACPAD will allow him to purchase two pieces of machinery that will speed up his research by allowing him to study 96 mutants at one time instead of one at a time.

Dr. Heng Wang, The DDC Clinic for Special Needs Children, Middlefield, OH

MACPAD Board of Directors awarded Dr. Heng Wang of the DDC Clinic in Middlefield, OH $4000 to continue his study into possible "protective" factors that allow some PKU patients to tolerate more phenylalanine in their diet than other PKU patients with the same PKU gene mutation. Please see Research Fund 2003 page for more detailed information.